The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 05, 2006
Filed:
Jun. 13, 2001
James H. Prestegard, Watkinsville, GA (US);
Nitin U. Jain, Athens, GA (US);
Hashim M. Al-hashimi, Athens, GA (US);
Laura C. Morris, Auburn, GA (US);
Andre P. Venot, Athens, GA (US);
James H. Prestegard, Watkinsville, GA (US);
Nitin U. Jain, Athens, GA (US);
Hashim M. Al-Hashimi, Athens, GA (US);
Laura C. Morris, Auburn, GA (US);
Andre P. Venot, Athens, GA (US);
Other;
Abstract
Methods of using NMR spectroscopy for identifying ligands that bind to structurally uncharacterized proteins, and improving the binding affinity of ligands for biological targets are disclosed. One aspect of the method includes preparing first NMR spectra of a first complex comprising the biological target and a paramagnetically labeled derivative of a first ligand, preparing a second NMR spectra of a second complex comprising the biological target and a second ligand, and analyzing the spectra to determine whether the second ligand binds to the biological target within the paramagnetic zone of the paramagnetically labeled derivative. The first and second steps may be performed simultaneously, consecutively, or in any order.