The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 05, 2006
Filed:
Oct. 25, 2001
Mamoru Ito, Kanagawa, JP;
Kimio Kobayashi, Kanagawa, JP;
Tatsutoshi Nakahata, Kyoto, JP;
Koichiro Tsuji, Tokyo, JP;
Sonoko Habu, Tokyo, JP;
Yoshio Koyanagi, Chiba, JP;
Naoki Yamamoto, Tokyo, JP;
Kazuo Sugamura, Miyagi, JP;
Kiyoshi Ando, Kanagawa, JP;
Tatsuji Nomura, Tokyo, JP;
Mamoru Ito, Kanagawa, JP;
Kimio Kobayashi, Kanagawa, JP;
Tatsutoshi Nakahata, Kyoto, JP;
Koichiro Tsuji, Tokyo, JP;
Sonoko Habu, Tokyo, JP;
Yoshio Koyanagi, Chiba, JP;
Naoki Yamamoto, Tokyo, JP;
Kazuo Sugamura, Miyagi, JP;
Kiyoshi Ando, Kanagawa, JP;
Tatsuji Nomura, Tokyo, JP;
Central Institute for Experimental Animals, Kanagawa, JP;
Abstract
The present invention provides an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells, and a method of producing such a mouse. This mouse is obtained by backcrossing a C.B-17-scid mouse with an NOD/Shi mouse, and further backcrossing an interleukin 2-receptor γ-chain gene-knockout mouse with the thus backcrossed mouse. It is usable for producing a human antibody and establishing a stem cell assay system, a tumor model and a virus-infection model.