The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 05, 2006
Filed:
Jul. 15, 2005
Sung Kee Kim, Daejeon, KR;
Hyunil Lee, Daejeon, KR;
Jong Chan Lim, Daejeon, KR;
Hoon Choi, Daejeon, KR;
Jae Hoon Jeon, Daejeon, KR;
Sang Youl Ahn, Daejeon, KR;
Sung Hee Lee, Suwon, KR;
Won Jun Yoon, Seoul, KR;
Sung Kee Kim, Daejeon, KR;
Hyunil Lee, Daejeon, KR;
Jong Chan Lim, Daejeon, KR;
Hoon Choi, Daejeon, KR;
Jae Hoon Jeon, Daejeon, KR;
Sang Youl Ahn, Daejeon, KR;
Sung Hee Lee, Suwon, KR;
Won Jun Yoon, Seoul, KR;
Panagene, Inc., Daejeon, KR;
Abstract
This application relates to monomers of the general formula (I) for the preparation of PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: wherein E is nitrogen or C—R'; J is sulfur or oxygen; R′, R1, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, R5 is H or protected or unprotected side chain of natural or unnatural α-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.