The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 05, 2006
Filed:
Sep. 20, 2002
Karel M. J. Brands, Jersey City, NJ (US);
Raymond Cvetovich, Scotch Plains, NJ (US);
Louis S. Crocker, Belle Mead, NJ (US);
Michael D. Ward, Westfield, NJ (US);
Amar J. Mahajan, Piscataway, NJ (US);
Robert M. Wenslow, East Windsor, NJ (US);
John M. Williams, Hillsborough, NJ (US);
Daniel R. Sidler, Whitehouse Station, NJ (US);
Charles Orella, Whitehouse Station, NJ (US);
Elizabeth S. Fisher, Cranbury, NJ (US);
Ronald Jobson, East Brunswick, NJ (US);
Karel M. J. Brands, Jersey City, NJ (US);
Raymond Cvetovich, Scotch Plains, NJ (US);
Louis S. Crocker, Belle Mead, NJ (US);
Michael D. Ward, Westfield, NJ (US);
Amar J. Mahajan, Piscataway, NJ (US);
Robert M. Wenslow, East Windsor, NJ (US);
John M. Williams, Hillsborough, NJ (US);
Daniel R. Sidler, Whitehouse Station, NJ (US);
Charles Orella, Whitehouse Station, NJ (US);
Elizabeth S. Fisher, Cranbury, NJ (US);
Ronald Jobson, East Brunswick, NJ (US);
Merck & Co. Inc., Rahway, unknown;
Abstract
A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than −5° C., c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a Calcohol at between −5 and −25° C.