The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 28, 2006
Filed:
Jul. 19, 2002
Marilyn C. Pike, Lincoln, MA (US);
Grushenka H. I Wolfgang, Oakland, CA (US);
Sharon A. Chen, Mountain View, CA (US);
Ralph M. Owen, Petaluma, CA (US);
Lynn B. Seely, Burlingame, CA (US);
Hans-peter Guler, Rye, NY (US);
Marilyn C. Pike, Lincoln, MA (US);
Grushenka H. I Wolfgang, Oakland, CA (US);
Sharon A. Chen, Mountain View, CA (US);
Ralph M. Owen, Petaluma, CA (US);
Lynn B. Seely, Burlingame, CA (US);
Hans-Peter Guler, Rye, NY (US);
Novartis Vaccines and Diagnostics, Inc., Emeryville, CA (US);
Abstract
A method for treating mammalian articular cartilage disorders, more particularly osteoarthritis, and trauma-related cartilage injuries using insulin-like growth factor I (IGF-I) is provided. The method comprises increasing the amount of IGF-I at the diseased or injured articular site to a therapeutically effective level that is capable of maintenance and/or regeneration of cartilage, which is beneficial to the long-term treatment of osteoarthritis and trauma-related injuries to cartilage tissues. In one embodiment of the invention, single doses of at least 0.01 mg of pharmaceutically effective IGF-I are administered intermittently such that the duration of time off of therapy is greater than the time on therapy, more preferably with a frequency of administration of about once per week or less.