Antitumoral compounds

Abstract

New spisulosine derivatives of use in treating tumors are of the formula (I) wherein: each X is the same or different, and represents H, OH, OR', SH, SR′, SOR′, SOR′, NO, NH, NHR′, N(R′), CN, halogen, C(═O)H, C(═O)CH, COH, COCH, substituted or unsubstituted C–Calkyl, substituted or unsubstituted C–Calkenyl, substituted or unsubstituted C–Calkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaromatic, or two groups X may together form ═O; Y is NR, OR, PR, SR, or halogen, wherein the number of substituents Ris selected to suit the valency and each Ris independently selected of H, OH, C(═O)R′, P(═O)R′R″, substituted or unsubstituted C–Calkyl, substituted or unsubstituted C–Calkenyl, substituted or unsubstituted C–Calkynyl, substituted or unsubstituted aryl, and wherein the dotted line indicates an optional double bond; each Z is the same different, and represents H, OH, OR′, SH, SR′, SOR′, SOR′, NO, NH, NHR′, N(R′), NHC(O)R′, CN, halogen, C(═O)H, C(═O)CH, COH, COCH, substituted or unsubstituted C–Calkyl, substituted or unsubstituted C–Calkenyl, substituted or unsubstituted C–Calkenyl, substituted or unsubstituted C–Calkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaromatic, or two groups Z may together form ═O; z is 0 to 25; y is to 0 to 20; Ris H, C(═O)R′, P(═O)R′R″, S(═O)R′R″, S(═O)R′, substituted or unsubstituted C–Calkyl, substituted or unsubstituted C–CAlkenyl, substituted or unsubstituted C–Calkynyl, substituted or unsubstituted aryl; Ris H, C(═O)R′, P(═O)R′R″, S(═O)R′R″, S(═O)R′, substituted or unsubstituted C–Calkyl, substituted or unsubstituted C–Calkenyl, substituted or unsubstituted C–Calkynyl, substituted or unsubstituted aryl; each of the R′, R″ groups is independently selected from the group consisting of H, OH, NO, NH, SH, CN, halogen, ═O, C(═O)H, C(═O)CH, COH, CO, substituted or unsubstituted C–Calkyl, substituted or unsubstituted C–Calkoxy, substituted or unsubstituted C–Calkenyl, substituted or unsubstituted C–Calkynl, substituted or unsubstituted aryl; there may be one or more unsaturations in the hydrocarbon backbone defined by the chain (II) and salts thereof; with the exception of a C–C2-amino-3-hydroxyalkane or a C–C2-amino-3-hydroxyalkene