The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 21, 2006

Filed:

Apr. 07, 2004
Applicants:

Takashi Tsukamoto, Ellicott City, MD (US);

Doris Stoermer, White Bear Lake, MN (US);

Dilrukshi Vitharana, Cambridge, MA (US);

Inventors:

Takashi Tsukamoto, Ellicott City, MD (US);

Doris Stoermer, White Bear Lake, MN (US);

Dilrukshi Vitharana, Cambridge, MA (US);

Assignee:

Guilford Pharmaceuticals Inc., Baltimore, MD (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07C 321/06 (2006.01); C07C 323/04 (2006.01); A61K 31/19 (2006.01); A61K 31/185 (2006.01); A61K 31/195 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to new thiolalkyl benzoic acids, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-β activity, inhibiting angiogenesis, and treating glutamate abnormalities, neuropathy, pain, compulsive disorders, prostate diseases, cancers, glaucoma, retinal disorders, and cancer.


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