The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 21, 2006
Filed:
Sep. 28, 2001
Margaret K. Hostetter, Milford, CT (US);
Denise Devore-carter, Guilford, CT (US);
Margaret K. Hostetter, Milford, CT (US);
Denise Devore-Carter, Guilford, CT (US);
Yale University, New Haven, CT (US);
Abstract
Antibodies and agents which can bind to the propeptide of the Int1p protein of yeast microorganisms such asare provided which can be useful in methods for treating or preventing infections arising from such microorganisms. Microorganisms expressing the Int1p protein, such asand, have shown an ability to immunomodulate host cells which allows infections of these microorganisms to thrive and become virulent. The peptide regions involved in the activation of the Int1p protein are isolated and targeted so as to provide a method of disrupting activation and allow for treatment or prevention of infection by microorganisms expressing the int1p protein. In one preferred embodiment of the invention, an antibody or agent which can bind to the propeptide of the Int1p protein fromis utilized in methods to prevent or treat infections caused byor other microorganisms expressing the Int1p protein.