The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 21, 2006
Filed:
Dec. 01, 1999
Ningning Miao, Palo Alto, CA (US);
Monica Wang, Marblehead, MA (US);
Nagesh K. Mahanthappa, Cambridge, MA (US);
Ping Jin, Boston, MA (US);
Kevin Pang, Belmont, MA (US);
Ningning Miao, Palo Alto, CA (US);
Monica Wang, Marblehead, MA (US);
Nagesh K. Mahanthappa, Cambridge, MA (US);
Ping Jin, Boston, MA (US);
Kevin Pang, Belmont, MA (US);
Curis, Inc., Cambridge, MA (US);
Abstract
It is shown here that hedgehog proteins possess novel activities beyond phenotype specification. Using cultures derived from the embryonic day 14.5 (E14.5) rat ventral mesencephalon, we show that hedgehog is also trophic for dopaminergic neurons. Interestingly, hedgehog not only promotes dopaminergic neuron survival, but also promotes the survival of midbrain GABA-immunoreactive (GABA-ir) neurons.