The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 21, 2006
Filed:
Aug. 09, 2002
Christopher John Love, Deurne, BE;
Jean Pierre Frans Van Wauwe, Beerse, BE;
Marc J. DE Brabander, Zoersel, BE;
Roger Clive Moses, Wadebridge, GB;
Mykhalyo Goncharenko, London, CA;
Ludwig Paul Cooymans, Beerse, BE;
Nele Vandermaesen, Olmen, BE;
Gaston Stanislas Marcella Diels, Ravels, BE;
Anthony William Sibley, Camelford, GB;
Caterina Noula, St. Columb Major, GB;
Christopher John Love, Deurne, BE;
Jean Pierre Frans Van Wauwe, Beerse, BE;
Marc J. De Brabander, Zoersel, BE;
Roger Clive Moses, Wadebridge, GB;
Mykhalyo Goncharenko, London, CA;
Ludwig Paul Cooymans, Beerse, BE;
Nele Vandermaesen, Olmen, BE;
Gaston Stanislas Marcella Diels, Ravels, BE;
Anthony William Sibley, Camelford, GB;
Caterina Noula, St. Columb Major, GB;
Janssen Pharmaceutica N.V., , BE;
Abstract
This invention concerns the use of a compound of formula (I) a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein Z is halo; Calkyl; Calkyl substituted with hydroxy, carboxyl, cyano, amino, mono- or di(Calkyl)amino, aminocarbonyl, mono- or di(Calkyl)aminocarbonyl, Calkyloxycarbonyl or Calkyloxy; polyhaloCalkyl; Calkyloxy; cyano; amino; aminocarbonyl; mono- or di(Calkyl)aminocarbonyl; Calkyloxycarbonyl; Calkylcarbonyloxy; HN—S(═O)—; mono- or di(Calkyl)amino-S(═O); —C(═N—R)NRR; Q is an optionally substituted carbocycle or an optionally substituted heterocycle; L is substituted phenyl or an optionally substituted monocyclic 5 or 6-membered partially saturated or aromatic heterocycle or a bicyclic partially saturated or aromatic heterocycle; aryl is optionally substituted phenyl; for the manufacture of a medicament for the prevention or the treatment of diseases mediated through TNF-α and/or IL-12.