The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 21, 2006
Filed:
Oct. 18, 2004
Applicants:
Sergei Gryaznov, San Mateo, CA (US);
Krisztina Pongracz, Oakland, CA (US);
Tracy Matray, San Lorenzo, CA (US);
Inventors:
Sergei Gryaznov, San Mateo, CA (US);
Krisztina Pongracz, Oakland, CA (US);
Tracy Matray, San Lorenzo, CA (US);
Assignee:
Geron Corporation, Menlo Park, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/70 (2006.01); C07H 21/00 (2006.01); C12Q 1/68 (2006.01);
U.S. Cl.
CPC ...
Abstract
Oligonucleotides with a novel sugar-phosphate backbone containing at least one internucleoside 3'-NHP(O)(S)O-5′ linkage, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive thiophosphoramidate oligonucleotides were found to retain the high RNA binding affinity of the parent oligonucleotide N3′→P5′ phosphoramidates and to exhibit a much higher acid stability.