The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 14, 2006
Filed:
Aug. 16, 2002
Kevin P. Baker, Darnestown, MD (US);
Napoleone Ferrara, San Francisco, CA (US);
Hanspeter Gerber, San Francisco, CA (US);
Mary E. Gerritsen, San Mateo, CA (US);
Audrey Goddard, San Francisco, CA (US);
Paul J. Godowski, Hillsborough, CA (US);
Austin L. Gurney, Belmont, CA (US);
Kenneth J. Hillan, San Francisco, CA (US);
Scot A. Marsters, San Carlos, CA (US);
James Pan, Etobicoke, CA;
Jean-philippe F. Stephan, Millbrae, CA (US);
Colin K. Watanabe, Moraga, CA (US);
P. Mickey Williams, Half Moon Bay, CA (US);
William I. Wood, Hillsborough, CA (US);
Weilan YE, Foster City, CA (US);
Kevin P. Baker, Darnestown, MD (US);
Napoleone Ferrara, San Francisco, CA (US);
Hanspeter Gerber, San Francisco, CA (US);
Mary E. Gerritsen, San Mateo, CA (US);
Audrey Goddard, San Francisco, CA (US);
Paul J. Godowski, Hillsborough, CA (US);
Austin L. Gurney, Belmont, CA (US);
Kenneth J. Hillan, San Francisco, CA (US);
Scot A. Marsters, San Carlos, CA (US);
James Pan, Etobicoke, CA;
Jean-Philippe F. Stephan, Millbrae, CA (US);
Colin K. Watanabe, Moraga, CA (US);
P. Mickey Williams, Half Moon Bay, CA (US);
William I. Wood, Hillsborough, CA (US);
Weilan Ye, Foster City, CA (US);
Genentech, Inc., South San Francisco, CA (US);
Abstract
Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.