The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 14, 2006
Filed:
Oct. 20, 2003
Stephen D Harrison, Albany, CA (US);
John a Hall, Rohnert Park, CA (US);
Maria Calderon-cacia, Castro Valley, CA (US);
Ziyang Zhong, Union City, CA (US);
Eric Y Fang, Oakland, CA (US);
Doris G Coit, Petaluma, CA (US);
Steve H Nguyen, San Francisco, CA (US);
Angelica Medina-selby, San Francisco, CA (US);
Stephen D Harrison, Albany, CA (US);
John A Hall, Rohnert Park, CA (US);
Maria Calderon-Cacia, Castro Valley, CA (US);
Ziyang Zhong, Union City, CA (US);
Eric Y Fang, Oakland, CA (US);
Doris G Coit, Petaluma, CA (US);
Steve H Nguyen, San Francisco, CA (US);
Angelica Medina-Selby, San Francisco, CA (US);
Chiron Corporation, Emeryville, CA (US);
Abstract
The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3α and GSK3β polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also provided are GSK3 polypeptides having at least one substituted amino acid that differs from wild-type GSK3, wherein the substituted amino acid is incapable of being phosphorylated. The invention finds use in providing methods of identifying and optimizing compounds useful for treating diseases mediated by GSK3 activity, including Alzheimer's disease, type 2 diabetes, and inflammation.