The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 07, 2006
Filed:
Apr. 21, 2004
Triaza- and tetraaza-anthracenedione derivatives, their preparation and their use as pharmaceuticals
Andreas Weichert, Norderstedt, DE;
Hartmut Strobel, Liederbach, DE;
Paulus Wohlfart, Bensheim, DE;
Marcel Patek, Tucson, AZ (US);
Martin Smrcina, Tucson, AZ (US);
Aleksandra Weichsel, Tucson, AZ (US);
Andreas Weichert, Norderstedt, DE;
Hartmut Strobel, Liederbach, DE;
Paulus Wohlfart, Bensheim, DE;
Marcel Patek, Tucson, AZ (US);
Martin Smrcina, Tucson, AZ (US);
Aleksandra Weichsel, Tucson, AZ (US);
Sanofi-aventis Deutschland GmbH, Frankfurt, DE;
Abstract
The present invention relates to triaza- and tetraaza-anthracenedione derivatives of the formula I, wherein A, B and Rto Rare as defined herein. The compounds of formula I are valuable pharmacologically active compounds. They are useful in the treatment of various disease states including cardiovascular disorders such as atherosclerosis, thrombosis, coronary artery disease, hypertension and cardiac insufficiency. They upregulate the expression of the enzyme endothelial nitric oxide (NO) synthase and can be applied in conditions in which an increased expression of said enzyme or an increased NO level or the normalization of a decreased NO level is desired. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.