The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 07, 2006
Filed:
Feb. 18, 2002
Francis J. Carr, Balmedie, GB;
Graham Carter, By Newmachar, GB;
Tim Jones, Babraham, GB;
Stephen Williams, Auchleven Insch, GB;
Anita Hamilton, Aberdeen, GB;
Francis J. Carr, Balmedie, GB;
Graham Carter, By Newmachar, GB;
Tim Jones, Babraham, GB;
Stephen Williams, Auchleven Insch, GB;
Anita Hamilton, Aberdeen, GB;
Merck Patent GmbH, Darmstadt, DE;
Abstract
The present invention relates to antibodies which are directed to the EGF receptor (HER1) to be administered especially to humans and in particular for therapeutic use in tumors. The antibodies are modified whereby the modification results in a reduced propensity for the antibody to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of anti-EGFR antibody 425 in its different forms and fragments thereof to result in Mab 425 variants that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo.