The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 07, 2006

Filed:

Dec. 30, 2004
Applicants:

John Milton, Slough, GB;

Nigel Vicker, Slough, GB;

Adrian Folkes, Slough, GB;

Shouming Wang, Slough, GB;

William Alexander Denny, Auckland, NZ;

Inventors:

John Milton, Slough, GB;

Nigel Vicker, Slough, GB;

Adrian Folkes, Slough, GB;

Shouming Wang, Slough, GB;

William Alexander Denny, Auckland, NZ;

Assignee:

Xenova Limited, Slough, GB;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 241/46 (2006.01); A61K 31/498 (2006.01);
U.S. Cl.
CPC ...
Abstract

A compound which is a benzo[a]phenazine-11-carboxamide derivative of formula (I) wherein each of Rto R, which are the same or different, is selected from hydrogen, halogen, hydroxyl, C–Calkoxy which is unsubstituted or substituted, heteroaryloxy, C–Calkyl which is unsubstituted or substituted, nitro, cyano, azido, amidoxime, COR, CON(R), OCON(R), SR, SOR, SOR, SON(R), N(R), NRSOR, N(SOR)NR(CH)CN, NRCOR, OCORor COR; These compounds are inhibitors of topoisomerase I and/or topoisomerase II and can be used to treat tumours, including tumours which express MDR.


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