The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 07, 2006
Filed:
May. 17, 2002
Stephen F. Brady, Philadelphia, PA (US);
James E. Bruce, Schwenksville, PA (US);
Elizabeth Chen-dodson, Souderton, PA (US);
Victor Garsky, Blue Bell, PA (US);
Yueming LI, New York, NY (US);
Mohinder Sardana, Lansdale, PA (US);
Jules A. Shafer, Gwynedd Valley, PA (US);
Xiaoting Tang, Lansdale, PA (US);
Stephen F. Brady, Philadelphia, PA (US);
James E. Bruce, Schwenksville, PA (US);
Elizabeth Chen-Dodson, Souderton, PA (US);
Victor Garsky, Blue Bell, PA (US);
Yueming Li, New York, NY (US);
Mohinder Sardana, Lansdale, PA (US);
Jules A. Shafer, Gwynedd Valley, PA (US);
Xiaoting Tang, Lansdale, PA (US);
Merck & Co., Inc., Rahway, NJ (US);
Abstract
The present invention provides synthetic β-secretase peptide substrates useful in various assays for measuring β-secretase activity. Antibodies that recognize the synthetic substrates and uses of the antibodies in various assays are disclosed. The herein disclosed peptide substrates are hydrolyzed at rates substantially faster than the attendant Swedish mutant APP from which the substrate sequences are derived.