The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 07, 2006
Filed:
Feb. 28, 2005
James Edward Summerton, Corvallis, OR (US);
James Edward Summerton, Corvallis, OR (US);
Gene Tools. LLC, Philomath, OR (US);
Abstract
Improved transporter compositions effective for detecting or killing cells in acidic areas of tumors are described. Each composition includes a transporter peptide which at pH 7.2 and above is poly-anionic and so repels from cells in normal tissues, but at lower pH in hypoxic areas of tumors the transporter peptide converts to a non-ionic lipophilic form which transports across membranes of cells. Each composition also includes a cargo component which can be pulled across cell membranes by the transporter peptide and which is effective for detecting or killing cells into which the transporter composition has entered.