The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 07, 2006
Filed:
Oct. 20, 2000
Donald P. Bottaro, Kensington, MD (US);
Safiye N. Atabey, Izmir, TR;
Jesus V. Soriano, Washington, DC (US);
Diane E. Breckenridge, Kensington, MD (US);
Zhu-jun Yao, Shanghai, CN;
Yang Gao, Branford, CT (US);
Terrence R. Burke, Jr., Bethesda, MD (US);
Donald P. Bottaro, Kensington, MD (US);
Safiye N. Atabey, Izmir, TR;
Jesus V. Soriano, Washington, DC (US);
Diane E. Breckenridge, Kensington, MD (US);
Zhu-Jun Yao, Shanghai, CN;
Yang Gao, Branford, CT (US);
Terrence R. Burke, Jr., Bethesda, MD (US);
Abstract
Disclosed are methods of inhibiting cell motility, for example, by inhibiting the binding between an intracellular transducer and a receptor protein tyrosine kinase, and more particularly by inhibiting hepatocyte growth factor (HGF) induced cell motility. The present invention also provides a method of inhibiting angiogenesis. The methods of the present invention employ peptides such as phosphotyrosyl mimetics. The present invention further provides methods of preventing and/or treating diseases, disorders, states, or conditions such as cancer, particularly metastatic cancer comprising administering to a mammal of interest one or more peptides of the present invention. Also disclosed are methods of blocking HGF, VEGF, or bFGF-stimulated migration, cell proliferation, and formation of capillary-like structures