The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 31, 2006
Filed:
Apr. 14, 2004
Joanne M. Smallheer, Yardley, PA (US);
Mimi L. Quan, Yardley, PA (US);
Shuaige Wang, West Chester, PA (US);
Gregory S. Bisacchi, Ringoes, NJ (US);
Joanne M. Smallheer, Yardley, PA (US);
Mimi L. Quan, Yardley, PA (US);
Shuaige Wang, West Chester, PA (US);
Gregory S. Bisacchi, Ringoes, NJ (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Abstract
The present invention provides compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt or hydrate form thereof, wherein the variables A, B, L, L, X, X, X, Xand W are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.