The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 31, 2006
Filed:
Jan. 14, 2003
Applicants:
George W. Gokel, Chesterfield, MO (US);
Paul H. Schlesinger, University City, MO (US);
Inventors:
George W. Gokel, Chesterfield, MO (US);
Paul H. Schlesinger, University City, MO (US);
Assignee:
Washington University, St. Louis, MO (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C08H 1/00 (2006.01); A61K 38/10 (2006.01); C08G 69/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention relates to amphiphiles for the formation of a synthetic ion channel in a phospholipid bilayer or biomembrane. The synthetic channel selectively transports chloride ions across the phospholipid bilayer or the membrane. Said amphiphiles impart ion permeability to the phospholipid bilayers or biomembrane and also modulate cellular volume in mammalian cells in vitro.