The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 31, 2006
Filed:
Aug. 03, 2001
Roland Buelow, Palo Alto, CA (US);
Josef Platzer, Munich, DE;
Wim Van Schooten, Sunnyvale, CA (US);
Jens-ulrich Buelow, Karlsruhe, DE;
Roland Buelow, Palo Alto, CA (US);
Josef Platzer, Munich, DE;
Wim van Schooten, Sunnyvale, CA (US);
Jens-Ulrich Buelow, Karlsruhe, DE;
Therapeutic Human Polyclonals, Inc., Mountain View, CA (US);
Abstract
This invention relates to humanized antibodies and antibody preparations produced from transgenic non-human animals. The non-human animals are genetically engineered to contain one or more humanized immunoglobulin loci which are capable of undergoing gene rearrangement and gene conversion in the transgenic non-human animals to produce diversified humanized immunoglobulins. The present invention further relates to novel sequences, recombination vectors and transgenic vectors useful for making these transgenic animals. The humanized antibodies of the present invention have minimal immunogenicity to humans and are appropriate for use in the therapeutic treatment of human subjects.