The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 31, 2006

Filed:

Nov. 15, 2002
Applicants:

Miyuki Nishimura, Kyoto, JP;

Mayumi Asano, Ogaki, JP;

Yuichi Ono, Ibaraki, JP;

Koji Morimoto, Neyagawa, JP;

Masakazu Takeuchi, Kyoto, JP;

Yoko Inoue, Kyoto, JP;

Toshio Imai, Kyoto, JP;

Yoshimi Takai, Kobe, JP;

Inventors:

Miyuki Nishimura, Kyoto, JP;

Mayumi Asano, Ogaki, JP;

Yuichi Ono, Ibaraki, JP;

Koji Morimoto, Neyagawa, JP;

Masakazu Takeuchi, Kyoto, JP;

Yoko Inoue, Kyoto, JP;

Toshio Imai, Kyoto, JP;

Yoshimi Takai, Kobe, JP;

Assignee:

Eisai Co., Ltd., Tokyo, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 21/02 (2006.01); C12N 15/63 (2006.01); C12N 1/21 (2006.01); C12N 1/19 (2006.01); C12N 5/10 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
Abstract

A mouse cDNA library from gene fragments encoding proteins localizing at cell-cell junctions was screened by a technique visualizing localization of a protein to to identify a junction-enriched and -associated protein, JEAP. GenBank homology search was performed based on the sequence. Based on the obtained sequence, a mouse cDNA library was screened to identify JEAP-2. By using prepared antibodies against these proteins, it was revealed that these proteins express specifically at tight junctions, in particular, tight junctions in exocrine glands.


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