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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 7129052 B1

PDFFull Text
Date of Patent:
Oct. 31, 2006

Filed:

Jul. 12, 2000

Peptides and their utility in modulation of behavior of cells expressing α3β1 integrins

Applicants:

David D. Roberts, Bethesda, MD (US);

Henry C. Krutzsch, Bethesda, MD (US);

Inventors:

David D. Roberts, Bethesda, MD (US);

Henry C. Krutzsch, Bethesda, MD (US);

Assignee:

The United States of America as represented by the Department of Health and Human Services, Washington, DC (US);

Attorney:

Townsend and Townsend and Crew LLP

Primary Examiner:

Maher M Haddad

Int. Cl.
CPC ...
G01N 33/53 (2006.01); A61K 38/04 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to a peptide comprising the sequence R-X-X-X-X-R, wherein Xis selected from the group consisting of N, Q, D and S; Xis selected from the group consisting of V, I and L; Xis selected from the group consisting of R and K; and Xis selected from the group consisting of V, I, L and F; Ris a hydrogen or a peptide of 1 to 6 amino acids, and acyl or an aryl group; and Ris a peptide of 1 to 3 amino acids, a hydroxide or an amide. The invention also relates to partial or full retro-inverso peptides comprising the above sequences. The invention also relates to peptide-substrate combination comprising a substrate suitable for cell growth and the peptide of the invention, and to a vascular graft and an artificial blood vessel comprising the peptide-substrate combination. The invention also relates to a pharmaceutical composition and a peptide conjugate comprising the peptide of the invention. The invention also relates to a method of inhibiting adhesion of a cell expressing α3β1 integrin to an cellular matrix, inhibiting α3β1-integrin-mediated cell motility, inhibiting α3β1-integrin mediated cell proliferation, promoting α3β1-integrin mediated cell proliferation and inhibiting angiogenesis utilizing the peptides of the invention.

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