The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 31, 2006
Filed:
Apr. 14, 2004
Paul David Grossman, Burlingame, CA (US);
Steven Fung, Palo Alto, CA (US);
Steven Michael Menchen, Fremont, CA (US);
Sam Lee Woo, Redwood City, CA (US);
Emily Susan Winn-deen, Foster City, CA (US);
Paul David Grossman, Burlingame, CA (US);
Steven Fung, Palo Alto, CA (US);
Steven Michael Menchen, Fremont, CA (US);
Sam Lee Woo, Redwood City, CA (US);
Emily Susan Winn-Deen, Foster City, CA (US);
Applera Coporation, Foster City, CA (US);
Abstract
Method and composition for detecting one or more selected polynucleotide regions in a target polynucleotide. In the method, a mixture of sequence-specific probes are reacted with the target polynucleotide under hybridization conditions, and the hybridized probes are treated to selectively modify those probes which are bound to the target polynucleotide in a base-specific manner. The resulting labeled probes include a polymer chain which imparts to each different-sequence probe, a distinctive ratio of charge/translational frictional drag, and a detectable label. The labeled probes are fractionated by electrophoresis in a non-sieving matrix, and the presence of one or more selected sequences in the target polynucleotide are detected according to the observed electrophoretic migration rates of the labeled probes in a non-sieving medium.