The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 31, 2006
Filed:
Dec. 11, 2001
Josef Burg, Weilheim, DE;
Alfred Engel, Tutzing, DE;
Reinhard Franze, Penzberg, DE;
Bernd Hilger, Penzberg, DE;
Hartmut Ernst Schurig, Munich, DE;
Wilhelm Tischer, Peissenberg, DE;
Manfred Wozny, Weilheim, DE;
Josef Burg, Weilheim, DE;
Alfred Engel, Tutzing, DE;
Reinhard Franze, Penzberg, DE;
Bernd Hilger, Penzberg, DE;
Hartmut Ernst Schurig, Munich, DE;
Wilhelm Tischer, Peissenberg, DE;
Manfred Wozny, Weilheim, DE;
Hoffmann-La Roche Inc., Nutley, NJ (US);
Abstract
The present invention refers to conjugates of erythropoietin with poly(ethylene glycol) comprising an erythropoietin glycoprotein having an N-terminal α-amino group and having the in vivo biological activity of causing bone marrow cells to increase production of reticulocytes and red blood cells and selected from the group consisting of human erythropoietin and analogs thereof which have the sequence of human erythropoietin modified by the addition of from 1 to 6 glycosylation sites or a rearrangement of at least one glycosylation site; said glycoprotein being covalently linked to one poly(ethylene glycol) group of the formula—CO—(CH)—(OCHCH)—ORwherein the —CO of the poly(ethylene glycol) group forms an amide bond with said N-terminal α-amino group; and wherein R is lower alkyl; x is 2 or 3; and m is from about 450 to about 1350.