The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 31, 2006
Filed:
Dec. 10, 2003
Magnus Höök, Houston, TX (US);
Joseph M. Patti, Cumming, GA (US);
Karen L. House-pompeo, Valdosta, GA (US);
Pietro Speziale, Pavia, IT;
Danny Joh, Houston, TX (US);
Martin J. Mcgavin, Etobicoke, CA;
Magnus Höök, Houston, TX (US);
Joseph M. Patti, Cumming, GA (US);
Karen L. House-Pompeo, Valdosta, GA (US);
Pietro Speziale, Pavia, IT;
Danny Joh, Houston, TX (US);
Martin J. McGavin, Etobicoke, CA;
The Texas A&M University System, College Station, TX (US);
University Degli Studi di Pavia, Pavia, IT;
University of Manitoba, Winnipeg, CA;
Abstract
Disclosed are antibodies that block the binding of fibronectin protein to fibronectin. Also disclosed are site specifically-mutated and truncated peptide epitopes derived from the fnbA and fnbB genes of, the fnbA and fnbB genes of, and the sfb gene of, and nucleic acid segments encoding these peptides and epitopes. The anti-(fibronectin binding site) antibodies, peptides and epitopes that give rise to antibodies that block the binding of fibronectin binding proteins to fibronectin, and DNA segments encoding these proteins and are of use in various screening, diagnostic and therapeutic applications including active and passive immunization and methods for the prevention of streptococcal and staphylococcal colonization in animals or humans. These DNA segments and the peptides derived therefrom are proposed to be of use directly in the preparation of vaccines and also for use as carrier proteins in vaccine formulations.