The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 24, 2006
Filed:
Mar. 14, 2005
Guisheng LI, Richmond, VA (US);
Jianxiu Liu, Richmond, VA (US);
Zhi-hui LU, Glen Allen, VA (US);
Frank Roschangar, Glen Allen, VA (US);
Chris Hugh Senanayake, Brookfield, CT (US);
Ming Shen, Waltham, MA (US);
Guisheng Li, Richmond, VA (US);
Jianxiu Liu, Richmond, VA (US);
Zhi-Hui Lu, Glen Allen, VA (US);
Frank Roschangar, Glen Allen, VA (US);
Chris Hugh Senanayake, Brookfield, CT (US);
Ming Shen, Waltham, MA (US);
Boehringer Ingelheim International, GmbH, Ingelheim, DE;
Abstract
The present invention provides a method for making substituted indole compounds of general formula III comprising the step of: (a) reacting a 2-bromoaniline or 2-chloroaniline of general formula (I) (I)wherein: X, R and Rare defined hereinwith a substituted acetylene of formula (II) wherein Rand Rare defined herein in the presence of a palladium catalyst, a ligand, and a base in a solvent at a suitable temperature to give a compound of formula (III);