The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 24, 2006
Filed:
May. 01, 2000
Ulrich Klar, Berlin, DE;
Wolfgang Schwede, Berlin, DE;
Werner Skuballa, Berlin, DE;
Bernd Buchmann, Hohen Neuendorf, DE;
Jens Hoffmann, Muhlenbeck, DE;
Rosemarie Lichtner, Berlin, DE;
Ulrich Klar, Berlin, DE;
Wolfgang Schwede, Berlin, DE;
Werner Skuballa, Berlin, DE;
Bernd Buchmann, Hohen Neuendorf, DE;
Jens Hoffmann, Muhlenbeck, DE;
Rosemarie Lichtner, Berlin, DE;
Schering AG, Berlin, DE;
Abstract
This invention describes the new 6-alkenyl- and 6-alkinyl-epothilone derivatives of general formula I in which R, R, R, R, R, R, R, R, R, A, Y, D, E, G, Y and Z are as defined in the specification. The compounds are useful in treating malignant tumours, for example, ovarian, stomach, colon, breast, adeno-, head and neck carcinomas, acute lymphocytic and myelocytic leukemia. In addition, these compounds are suitable for anti-angiogenesis therapy as well as for treatment of chronic inflammatory diseases such as psoriasis and arthritis. Methods of use and preparation of the compounds are also described.