The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 24, 2006
Filed:
Dec. 07, 2005
Xin Wei Wang, Rockville, MD (US);
Curtis C. Harris, Garrett Park, MD (US);
Albert J. Fornace, Jr., Bethesda, MD (US);
Jill D. Coursen, Boston, MA (US);
Qimin Zhan, Pittsburgh, PA (US);
Xin Wei Wang, Rockville, MD (US);
Curtis C. Harris, Garrett Park, MD (US);
Albert J. Fornace, Jr., Bethesda, MD (US);
Jill D. Coursen, Boston, MA (US);
Qimin Zhan, Pittsburgh, PA (US);
Abstract
The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.