The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 24, 2006
Filed:
May. 05, 2000
Daniel Tim Curtis, South San Francisco, CA (US);
George Ross Francis, South San Francisco, CA (US);
Michael Christopher Ellis, South San Francisco, CA (US);
David Andrew Ruddy, South San Francisco, CA (US);
Sharmon Monique Nicoll, South San Francisco, CA (US);
Garth Joseph Mcgrath, South San Francisco, CA (US);
Daniel Tim Curtis, South San Francisco, CA (US);
George Ross Francis, South San Francisco, CA (US);
Michael Christopher Ellis, South San Francisco, CA (US);
David Andrew Ruddy, South San Francisco, CA (US);
Sharmon Monique Nicoll, South San Francisco, CA (US);
Garth Joseph McGrath, South San Francisco, CA (US);
Exelixis, Inc., So. San Francisco, CA (US);
Abstract
The invention provides methods and compositions relating to pen polypeptides having pen-specific structure and activity, related polynucleotides and modulators of pen function. The invention provides isolated pen hybridization probes and primers capable of specifically hybridizing with natural pen genes, pen-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis (e.g. genetic hybridization screens for pen transcripts), therapy (e.g. pen inhibitors to modulate APP processing) and in the biopharmaceutical industry (e.g. as immunogens, reagents for screening chemical libraries for lead pharmacological agents, etc.).