The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 24, 2006
Filed:
Aug. 09, 2002
Martin Stanton, Stow, MA (US);
David Epstein, Belmont, MA (US);
Nobuko Hamaguchi, Framingham, MA (US);
Markus Kurz, Newton, MA (US);
Tony Keefe, Cambridge, MA (US);
Charles Wilson, Concord, MA (US);
Dilara Grate, Waltham, MA (US);
Kristin A. Marshall, Arlington, MA (US);
Thomas G. Mccauley, Somerville, MA (US);
Jeffrey C. Kurz, Somerville, MA (US);
Martin Stanton, Stow, MA (US);
David Epstein, Belmont, MA (US);
Nobuko Hamaguchi, Framingham, MA (US);
Markus Kurz, Newton, MA (US);
Tony Keefe, Cambridge, MA (US);
Charles Wilson, Concord, MA (US);
Dilara Grate, Waltham, MA (US);
Kristin A. Marshall, Arlington, MA (US);
Thomas G. McCauley, Somerville, MA (US);
Jeffrey C. Kurz, Somerville, MA (US);
Archemix Corp., Cambridge, MA (US);
Abstract
Methods for engineering a nucleic acid sensor molecule are provided. Biosensors comprise a plurality of nucleic acid sensor molecules labeled with a first signaling moiety and a second signaling moiety. The nucleic acid sensor molecules recognizes target molecules which do not naturally bind to DNA. Binding of a target molecule to the sensor molecules triggers a change in the proximity of the signaling moieties which leads to a change in the optical properties of the nucleic acid sensor molecules on the biosensor. Reagents and systems for performing the method are also provided. The method is useful in diagnostic applications and drug optimization.