The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 17, 2006
Filed:
Mar. 08, 2002
Nikola Pavletich, New York, NY (US);
Michael Finnin, Alexandria, VA (US);
Jill Donigian, North Arlington, NJ (US);
Victoria M. Richon, Rye, NY (US);
Richard A. Rifkind, New York, NY (US);
Paul A. Marks, Washington, CT (US);
Ronald Breslow, Englewood, NJ (US);
Nikola Pavletich, New York, NY (US);
Michael Finnin, Alexandria, VA (US);
Jill Donigian, North Arlington, NJ (US);
Victoria M. Richon, Rye, NY (US);
Richard A. Rifkind, New York, NY (US);
Paul A. Marks, Washington, CT (US);
Ronald Breslow, Englewood, NJ (US);
Sloan-Kettering Institute for Cancer Research, New York, NY (US);
Abstract
The present invention provides three-dimensional structural information from the hyperthermophilic bacteriumwhich is a histone deacetylase-like protein (HDLP). HDLP shares 35.2% amino acid sequence identity with human histone deacetylase (HDAC1). The present invention further provides three-dimensional structural information of HDLP bound by inhibitor molecules. The three-dimensional structural information of the present invention is useful to design, isolate and screen deacetylase inhibitor compounds capable of inhibiting HDLP, HDAC family members and HDLP-related molecules. The invention also relates to nucleic acids encoding a mutant HDLP which facilitates the determination of the three-dimensional structure of HDLP in the presence of a zinc atom.