Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses

Abstract

Compounds having activity against production of an inflammatory cytokine of formula (I)': A′ is pyrrole; Ris phenyl or naphthyl; Ris pyridyl or pyrimidinyl; Ris (IIa)′, (IIb)′ or (IIc)′: m′ is 1; E′ is nitrogen; D′ is >C(R)—, Ris hydrogen, Substituent α′ or Substituent β′; B′ is nitrogen-containing 5-membered heterocyclic; Ris 1 to 3 substituents from Substituent α′, Substituent β′ and Substituent γ′; Rand Rare bonded to two atoms of the pyrrole adjacent to the pyrrole atom bonded to R; Substituent α′ is hydroxyl, nitro, cyano, halogen, alkoxy, halogeno alkoxy, alkylthio, halogeno alkylthio or —NRR; Rand Rare hydrogen, alkyl, alkenyl, alkynyl, aralkyl or alkylsulfonyl, or Rand Rwith the nitrogen atom form a heterocyclyl; Substituent β′ is alkyl, alkenyl, alkynyl, aralkyl or cycloalkyl; Substituent γ′ is oxo, hydroxyimino, alkoxyimino, alkylene, alkylenedioxy, alkylsulfinyl, alkylsulfonyl, aryl, aryloxy, alkylidenyl or aralkylidenyl.