The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 17, 2006
Filed:
Oct. 14, 2003
Lijun Sun, Harvard, MA (US);
Mitsunori Ono, Lexington, MA (US);
Yumiko Wada, Billerica, MA (US);
Weiwen Ying, Ayer, MA (US);
Teresa Przewloka, Tewksbury, MA (US);
Elena Kostik, Arlington, MA (US);
Lijun Sun, Harvard, MA (US);
Mitsunori Ono, Lexington, MA (US);
Yumiko Wada, Billerica, MA (US);
Weiwen Ying, Ayer, MA (US);
Teresa Przewloka, Tewksbury, MA (US);
Elena Kostik, Arlington, MA (US);
Synta Pharmaceuticals Corp., Lexington, MA (US);
Abstract
This invention features a compound of formula (I): Ris aryl or heteroaryl; each of Rand R, independently, is H, halogen, CN, alkyl, OR, or NRR; Ris H, halogen, CN, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, heterocyclyl, OR, OC(O)R, OC(O)NRR, NRR, NRC(O)R, NRS(O)R, NRS(O)R, NRC(O)NRR, NRC(S)NRR, NRC(NR)NRR, NRC(O)OR, S(O)NRR, S(O)NRR, S(O)R, S(O)R, C(O)R, C(O)OR, or C(O)NRR; Ris H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; A is O, S, S(O), S(O), or NR; B is N or CR; X is O, S, S(O), S(O), NR, or C(O); Y is a covalent bond, C(O), C═NR, O, S, S(O), S(O), or NR; Z is N or CH; each of U and V, independently, is N or CR; and W is O, S, or NR; in which each of R, R, R, and R, independently, is H, alkyl, aryl, heteroaryl, cyclyl, or heterocyclyl; Ris H, alkyl, aryl, acyl, or sufonyl; and Ris H, alkyl, aryl, acyl, sulfonyl, alkoxyl, amino, ester, amide, CN, or halogen. The compound is useful for treating an interleukin-12 overproduction-related disorder.