The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 17, 2006
Filed:
Dec. 16, 2002
Marcus Karl Koppitz, Berlin, DE;
Hans Peter Muhn, Berlin, DE;
Kenneth Jay Shaw, Brookside, NJ (US);
Holger Hess-stump, Berlin, DE;
Klaus Paulini, Maintal, DE;
Marcus Karl Koppitz, Berlin, DE;
Hans Peter Muhn, Berlin, DE;
Kenneth Jay Shaw, Brookside, NJ (US);
Holger Hess-Stump, Berlin, DE;
Klaus Paulini, Maintal, DE;
Zentaris AG, Frankfurt, DE;
Abstract
This invention provides new tetrahydrocarbazole derivatives that act as ligands for G-protein-coupled receptors (GPCR), especially as antagonists of the gonadotropin-releasing hormone (GnRH). A pharmaceutical composition that contains these new tetrahydrocarbazole derivatives as well as a process for the production of the new tetrahydrocarbazole derivatives are also provided. Moreover, this invention relates to the administration of tetrahydrocarbazole derivatives for treating pathologic conditions that are mediated by GPCR, especially for inhibiting GnRH, in mammals, especially humans, who require such an administration, as well as the use of tetrahydrocarbazole derivatives for the production of a pharmaceutical agent for treating GPCR-mediated pathologic conditions, especially for inhibiting GnRH.