Quinuclidine derivatives and medicinal compositions containing the same

Abstract

A compound of formula (I), wherein B is a phenyl ring, a 5 to 10 membered heteroaromatic group containing one or more heteroatoms, or a naphthalenyl, 5,6,7,8-tetrahydronaphthalenyl, benzo[1,3]dioxolyl, or biphenyl group; R, Rand Reach independently represent a hydrogen or halogen atom, or a hydroxy group, a phenyl group, —OR, —SR, —NRR, —NHCOR, —CONRR, —CN, —NO, —COORor CFgroup, or a strait or branched, substituted or unsubstituted lower alkyl group, wherein Rand Reach independently represent a hydrogen atom, a straight or branched lower alkyl group, or together form an alicyclic ring; or Rand Rtogether form an aromatic or alicyclic ring or a heterocyclic group. n is an integer from 0 to 4; A represents a group selected from —CH—, —CH═CR—, —CR═CH—, —CRR—, —CO—, —O—, —S—, —S(O)—, —S(O)— and NR, wherein Rand Reach independently represent a hydrogen atom, a straight or branched lower alkyl group, or together form an alicyclic ring; m is an integer from 0 to 8, provided that when m=0, A is not —CH—; p is an integer from 1 to 2 and the substitution in the azonia bicyclic ring may be in the 2, 3 or 4 position including all possible configurations of the asymmetric carbons; Rrepresents a group of structure: (Formulae II) wherein Rrepresents a hydrogen or halogen atom, a hydroxy group, an alkoxy group, a nitro group, a cyano group, —CORor —NRR, wherein Rand Rare identical or different and are selected from hydrogen and straight or branched lower alkyl groups, or a straight or branched, substituted or unsubstituted lower alkyl group; Rrepresents an alkyl group of 1 to 7 carbon atoms, an alkenyl group containing 2 to 7 carbon atoms, or a group of formula (III) wherein q=1 or 2 and Riss a defined above; Rrepresents a hydrogen atom, a hydroxy group, a methyl group or a —CHOH group; and Xrepresents a pharmaceutically acceptable anion of a mono or polyvalent acid .