The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 10, 2006
Filed:
Mar. 14, 2005
Martin K. Safo, Richmond, VA (US);
Richmond Danso-danquah, Richmond, VA (US);
Gajanan S. Joshi, Glen Allen, VA (US);
Donald J. Abraham, Windermere, FL (US);
Martin K. Safo, Richmond, VA (US);
Richmond Danso-Danquah, Richmond, VA (US);
Gajanan S. Joshi, Glen Allen, VA (US);
Donald J. Abraham, Windermere, FL (US);
Virginia Commonwealth University, Richmond, VA (US);
Abstract
Compounds for the treatment of sickle-cell disease, and methods for their use are provided. The compounds have a dual mode of action. First, binding of the compounds to hemoglobin increases the oxygen affinity of both normal and sickle hemoglobin. Secondly, binding of these compounds to the N-terminal amino acid of sickle hemoglobin results in destabilization of potential contacts between sickle hemoglobin molecules, preventing polymerization and the formation of fibrous precipitates of the sickle hemoglobin. The compounds are also useful for inducing hypoxia, e.g. to augment cancer treatments.