The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 10, 2006
Filed:
Jun. 06, 2001
Klemens Kaupmann, Lörrach, DE;
Bernhard Bettler, Allschwil, CH;
Helmut Bittiger, Freiburg, DE;
Wolfgang Fröstl, Basel, CH;
Stuart J Mickel, Lausen, CH;
Klemens Kaupmann, Lörrach, DE;
Bernhard Bettler, Allschwil, CH;
Helmut Bittiger, Freiburg, DE;
Wolfgang Fröstl, Basel, CH;
Stuart J Mickel, Lausen, CH;
Novartis AG, Basel, CH;
Abstract
The present invention provides purified GABAreceptors and receptor proteins derived from rat and human sources, as well as nucleic acids which encode such proteins. The proteins and nucleic acids of the invention share significant homology with the GABAreceptor and the DNA encoding it as specifically disclosed herein. The invention moreover provides methods for isolating other members of the GABAreceptor family using DNA cloning technology and probes derived from the sequences provided herein, as well as novel members of the GABAreceptor family isolated by such methods. Furthermore, the invention relates to the use of GABAreceptors and receptor proteins and cells transformed with a gene encoding a GABAreceptor protein in a method for identifying and characterising compounds which modulate the activity of the GABAreceptor, such as GABAreceptor agonists and antagonists, which may be useful as pharmacological agents for the treatment of disorders associated with the central and peripheral nervous systems.