The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 26, 2006
Filed:
Mar. 27, 2002
Toshimi Okada, Ibaraki, JP;
Nobuyuki Kurusu, Ibaraki, JP;
Keigo Tanaka, Ibaraki, JP;
Seiji Yoshikawa, Ibaraki, JP;
Daisuke Shinmyo, Ibaraki, JP;
Nobuhisa Watanabe, Ibaraki, JP;
Hironori Ikuta, Ibaraki, JP;
Hironobu Hiyoshi, Ibaraki, JP;
Takao Saeki, Ibaraki, JP;
Mamoru Yanagimachi, Ibaraki, JP;
Masashi Ito, Chiba, JP;
Toshimi Okada, Ibaraki, JP;
Nobuyuki Kurusu, Ibaraki, JP;
Keigo Tanaka, Ibaraki, JP;
Seiji Yoshikawa, Ibaraki, JP;
Daisuke Shinmyo, Ibaraki, JP;
Nobuhisa Watanabe, Ibaraki, JP;
Hironori Ikuta, Ibaraki, JP;
Hironobu Hiyoshi, Ibaraki, JP;
Takao Saeki, Ibaraki, JP;
Mamoru Yanagimachi, Ibaraki, JP;
Masashi Ito, Chiba, JP;
Eisai Co., Ltd., Tokyo, JP;
Abstract
An excellent squalene synthase inhibitor is provided. Specifically, what is provided is a compound (I) represented by the following formula, a salt thereof or a hydrate of them. In formula (I), Rrepresents an optionally substituted vinyl group or an aromatic ring which may be substituted. Also, n is an integer of 0 to 2. Further, X, Y and Z are the same as or different from each other and each represents an optionally substituted carbon atom, or an optionally substituted nitrogen atom, sulfur atom or oxygen atom, and Y optionally represents a single bond, and when Y represents the single bond, the ring to which X, Y and Z belong is a 5-membered ring. Also in the formula, CyA represents a 5- to 14 membered non-aromatic cyclic amino group or non-aromatic cyclic amido group which may be substituted, and the non-aromatic cyclic amino group or the non-aromatic cyclic amido group optionally having an oxygen atom or a sulfur atom. Finally, W represents a chain