The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 26, 2006
Filed:
Dec. 12, 2001
Applicants:
Shi-kun Huang, Castro Valley, CA (US);
Samuel Zalipsky, Redwood City, CA (US);
Wei-ming Zhang, San Francisco, CA (US);
Inventors:
Shi-Kun Huang, Castro Valley, CA (US);
Samuel Zalipsky, Redwood City, CA (US);
Wei-Ming Zhang, San Francisco, CA (US);
Assignee:
ALZA Corporation, Mountain View, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/127 (2006.01);
U.S. Cl.
CPC ...
Abstract
A liposome composition for delivery of a nucleic acid in vivo or ex vivo is described. The liposomes in the composition are comprised of (i) a lipid that is neutral in charge at physiologic pH and positively charged at pH values less than physiologic pH and (ii) a lipid joined to a hydrophilic polymer by a dithiobenzyl linkage. The liposomes are associated with a nucleic acid for delivery to a cell.