The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 19, 2006
Filed:
Jan. 24, 2005
Applicants:
Antoni Torrens Jover, Barcelona, ES;
Helmut H. Buschmann, Barcelona, ES;
Stefan Dahmen, Aachen, DE;
Matthias Lormann, Aachen, DE;
Inventors:
Antoni Torrens Jover, Barcelona, ES;
Helmut H. Buschmann, Barcelona, ES;
Stefan Dahmen, Aachen, DE;
Matthias Lormann, Aachen, DE;
Assignee:
Primary Examiner:
Int. Cl.
CPC ...
C07D 231/12 (2006.01);
U.S. Cl.
CPC ...
Abstract
A process is described for the preparation of a precursor alcohol of Cizolirtine, (±)-2-[phenyl(1-methyl-1H-pyrazol-5-yl)methoxy]-N,N-dimethylethanamine and its enantiomers. The process involves the asymmetric addition of a metalated phenyl reagent to a pyrazolcarbaldehyde in the presence of a chiral ligand to yield chiral alcohols. The chiral alcohols are further O-alkylated to yield Cizolirtine or its enantiomers.