The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 19, 2006
Filed:
Dec. 08, 2003
Applicants:
Nurulain Zaveri, San Jose, CA (US);
Wan-ru Chao, Sunnyvale, CA (US);
Ahlem Bensari, Edinburgh, GB;
Inventors:
Assignee:
SRI International, Menlo Park, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 311/02 (2006.01); A61K 31/352 (2006.01);
U.S. Cl.
CPC ...
Abstract
Novel compounds useful as chemotherapeutic and chemopreventive agents are provided. The compounds are analogs of polyphenol catechins that occur in green tea, such as epigallocatichin-3-gallate (EGCG), and have the structure of formula (I) wherein Rthrough Rare defined herein. Preferred Rmoieties are selected from O, S, NH and CH, and in exemplary compounds, Ris O and Ris a tri-substituted aroyloxy substituent, such as a 3,4,5-substituted benzoyloxy group. Pharmaceutical compositions are provided as well, as are methods of chemotherapy and chemoprevention.