The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 19, 2006

Filed:

Nov. 19, 2001
Applicants:

Neil J Press, Horsham, GB;

Roger J Taylor, Horsham, GB;

Inventors:

Neil J Press, Horsham, GB;

Roger J Taylor, Horsham, GB;

Assignee:

Novartis AG, Basel, CH;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/427 (2006.01); A61K 31/497 (2006.01); A61K 31/4436 (2006.01); C07D 417/14 (2006.01); C07D 277/42 (2006.01);
U.S. Cl.
CPC ...
Abstract

Compounds of formula (I) in free or salt form, where A is a C-Cmonovalent aromatic group. Ris hydrogen, phenyl optionally substituted by one or more substituents selected from halogen, cyano, hydroxy, C–C-alkyl, C–C-haloalkyl, C–C-alkoxy, C–C-alkoxy-C–C-alkyl or acyloxy, or a 5- or 6-membered monovalent heterocyclic group, Ris hydrogen, C-C-alkyl, acyl or CON(R)R, provided that Ris C–C-alkyl, acyl or CON(R)Rwhen Ris hydrogen, Rand Rare each independently hydrogen, or C–C-alkyl, together with the nitrogen atom to which they are attached denote a 5- or 6-membered heterocyclic group, and Z, Z, Zand Zare each independently N or CR, at least one of them being CR, and Ris hydrogen, C–C-alkyl or C–C-alkoxy. The compounds are useful as adenosine receptor antagonists, particularly in the treatment of inflammatory or obstrucive airways diseases


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