The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 19, 2006
Filed:
Jul. 08, 2003
Applicants:
Jeffrey C. Moore, Westfield, NJ (US);
Michael G. Sturr, Mountainside, NJ (US);
Kathleen Mclaughlin, Edison, NJ (US);
Jaehon Kim, Fort Lee, NJ (US);
Inventors:
Jeffrey C. Moore, Westfield, NJ (US);
Michael G. Sturr, Mountainside, NJ (US);
Kathleen McLaughlin, Edison, NJ (US);
Jaehon Kim, Fort Lee, NJ (US);
Assignee:
Merck & Co., Inc., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P 7/42 (2006.01); C12P 7/60 (2006.01); C12P 7/62 (2006.01); C12N 9/02 (2006.01);
U.S. Cl.
CPC ...
Abstract
A process for preparing (R)-hydroxy ester (II) from alpha-keto ester I comprising adding the alpha-keto ester I to a mixture comprising the ketoreductase enzyme and non-ketoreductase enzyme components, wherein the ketoreductase enzyme has a molecular weight between 36000 and 38000, and wherein the ketoreductase enzyme has an N-terminal amino acid sequence selected from the group of sequences consisting of