The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 19, 2006
Filed:
Oct. 30, 2002
Michael Sherman, San Francisco, CA (US);
Warner Greene, San Francisco, CA (US);
Ulrich Schubert, Hamburg, DE;
Victor Wray, Braunschweig, DE;
Uwe Tessmer, Hamburg, DE;
Peter Henklein, Berlin, DE;
Karsten Bruns, Hamburg, DE;
Michael Sherman, San Francisco, CA (US);
Warner Greene, San Francisco, CA (US);
Ulrich Schubert, Hamburg, DE;
Victor Wray, Braunschweig, DE;
Uwe Tessmer, Hamburg, DE;
Peter Henklein, Berlin, DE;
Karsten Bruns, Hamburg, DE;
The J. David Gladstone Institutes, San Francisco, CA (US);
Abstract
The present invention provides screening methods for identifying a compound that induces loss of the lentiviral protein Vpr; screening methods for identifying compounds that inhibit the peptidyl-prolyl cis/trans isomerase (PPIase) activity of a protein that catalyzes cis-trans isomerization of cis-peptidylprolyl bonds in Vpr; and compounds identified by the screening methods. The compounds are useful for treating a lentiviral infection. The present invention further provides methods of inducing loss of the lentiviral protein Vpr; methods of inhibiting lentivirus viral replication; and methods of treating a lentivirus infection in an individual. The methods generally involve administering to an individual infected with the lentivirus an effective amount of a compound that induces Vpr loss and/or that inhibits PPIase activity of a protein that catalyzes cis-trans isomerization of cis-peptidylprolyl bonds in Vpr.