The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 12, 2006

Filed:

Oct. 14, 2003
Applicants:

Qingjie Ding, Bridgewater, NJ (US);

Paul Gillespie, Westfield, NJ (US);

Kyungjin Kim, Livingston, NJ (US);

Warren William Mccomas, Denville, NJ (US);

Agostino Perrotta, Bloomfield, NJ (US);

Inventors:

Qingjie Ding, Bridgewater, NJ (US);

Paul Gillespie, Westfield, NJ (US);

Kyungjin Kim, Livingston, NJ (US);

Warren William McComas, Denville, NJ (US);

Agostino Perrotta, Bloomfield, NJ (US);

Assignee:

Hoffmann-La Roche Inc., Nutley, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 239/02 (2006.01); C07D 413/00 (2006.01); C07D 417/00 (2006.01); C07D 419/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

Disclosed are novel diaminothiazoles that are selective inhibitors of Cdk4. These compounds and their pharmaceutically acceptable salts and esters are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, lung and prostate tumors. Also disclosed are pharmaceutical compositions containing these compounds as well as intermediates useful in the preparation of the compounds.


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