The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 12, 2006
Filed:
Aug. 02, 2002
Bradley L. Smith, Marblehead, MA (US);
Katherine Crosby, Middleton, MA (US);
Jiong Wu, Salem, MA (US);
Bradley L. Smith, Marblehead, MA (US);
Katherine Crosby, Middleton, MA (US);
Jiong Wu, Salem, MA (US);
Cell Signalling Technology, Inc., Danvers, MA (US);
Abstract
The invention provides monoclonal antibodies that bind the estrogen receptor α (ER α) when phosphorylated at serine 118 (Ser118) in the N-terminal domain, but do not bind to ER α when not phosphorylated at this site. Also provided are methods for determining the phosphorylation of ER α in a biological sample, profiling ER α activation in a test tissue, and identifying a compound that modulates phosphorylation of ER α in a test tissue, by using the disclosed monoclonal antibodies. The sample or test tissue may be taken from a subject suspected of having cancer, such as breast cancer. Kits comprising the phospho-ER α (Ser118) monoclonal antibodies of the invention are also provided.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile