Gastrin and cholecystokinin receptor lignads (iv)

Abstract

Compounds of the formula (I) or (II) and their pharmaceutically acceptable salts are ligands at gastrin and/or chole-cystokinin receptors n is from 1 to 4; Ris Cto Chydrocarbyl wherein up to two C atoms may optionally be replaced by N, O and/or S atoms and up to three H atoms may optionally be replaced by halogen atoms; Z is —(NR)—CO—(NR)-(wherein a is 0 or 1, b is 0 or 1, and Rand Rare independently selected from H, Me, Et, Pr, Bn), —CO—NR—CH—CO—NR—, —CO—O—, —CH—CH—, —CH═CH—, CH—NR— or a bond; Q is RV, or(a) wherein Ris —CH—; —CH—; or(b) Rand R, together with the nitrogen atom to which Ris attached, form a piperidine or pyrrolidine ring which is substituted by V; V is —CO—NH—SO-Ph, —SO—NH—CO-Ph, CHOH, or a group of the formula —RU, (wherein U is —COOH, tetrazolyl, —CONHOH— or —SOH; and Ris a bond; Cto Chydrocarbylene, optionally substituted by hydroxy, amino or acetamino; —O—(Cto Calkylene)-; —SONR—CHR—; —CO—NR—CHR—, Rand Rbeing independently selected from H and methyl; or —NH—(CO)—CH—, c being 0 or 1); m is 1 or 2; q is from 0 to 2, with the proviso that q is 1 or 2 when Z is a bond); Compositions comprising a compound of formula (I) or (II) are also described.