The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 12, 2006
Filed:
Nov. 30, 2001
Stephen Thomas Davis, Durham, NC (US);
Scott Howard Dickerson, Chapel Hill, NC (US);
Stephen Vernon Frye, Durham, NC (US);
Philip Anthony Harris, Raleigh, NC (US);
Robert Neil Hunter, Iii, Raleigh, NC (US);
Lee Frederick Kuyper, Durham, NC (US);
Karen Elizabeth Lackey, Hillsborough, NC (US);
Michael Joseph Luzzio, Groton, CT (US);
James Marvin Veal, Apex, NC (US);
Duncan Herrick Walker, Summit, NJ (US);
Stephen Thomas Davis, Durham, NC (US);
Scott Howard Dickerson, Chapel Hill, NC (US);
Stephen Vernon Frye, Durham, NC (US);
Philip Anthony Harris, Raleigh, NC (US);
Robert Neil Hunter, III, Raleigh, NC (US);
Lee Frederick Kuyper, Durham, NC (US);
Karen Elizabeth Lackey, Hillsborough, NC (US);
Michael Joseph Luzzio, Groton, CT (US);
James Marvin Veal, Apex, NC (US);
Duncan Herrick Walker, Summit, NJ (US);
SmithKline Beecham Corporation, Philadelphia, PA (US);
Abstract
Compounds of formula (I): wherein X is N, CH, CCF, or C(Caliphatic); Ris sulfonic acid, Caliphatic-sulfonyl, sulfonyl-Caliphatic, Caliphatic-sulfonyl-Caliphatic, Caliphatic-amino, R-sulfonyl, Rsulfonyl-Caliphatic, R-aminosulfonyl, R-aminosulfonyl-Caliphatic, R-sulfonylamino, R-sulfonylamino-Caliphatic, aminosulfonylamino, di-Caliphatic amino, di-Caliphatic aminocarbonyl, di-Caliphatic aminosulfonyl, di-Caliphatic amino, di-Caliphatic aminocarbonyl, di-Caliphatic aminosulfonyl-Caliphatic, (R)-Arylamino, (R)-Arylsulfonyl, (R)-Aryl-aminosulfonyl, (R)-Aryl-sulfonylamino, Het-amino, Het-sulfonyl, Het-aminosulfonyl, aminoiminoamino, or aminoiminoaminosulfonyl, Ris hydrogen; and further wherein Rand Rare optionally joined to form a fused ring, pharmaceutical formulations comprising them and their use in therapy, especially in the treatment of diseases mediated by CDK2 activity, such as alopecia induced by cancer chemotherapy or radiotherapy.